This chapter seeks to build upon notions of a Paracelsian compromise to offer an alternative view of the fate of Galenic simples in early modern medical praxes, one of continued thriving rather than inevitable decline. Delving beyond printed works and exploring manuscript recipe books produced across the early modern period in England, this chapter will show that Galenic medicine continued to thrive despite the rise of alternate medical praxes such as Paracelsian iatrochemistry. These recipe books offer a crucial glimpse into worlds of medical practices that printed treatises obscure, offering valuable insights into the commonplace medical practices of large swathes of society, rather than merely those of the more elite learned physicians. The narrative presented here, then, is one told by the historical actors themselves, drawing upon the lived experiences of domestic healers rather than spotlighting the many nuanced and often vitriolic scholarly debates that raged amongst the medical elite.