This chapter explores trauma-informed care (TIC) as a framework for supporting individuals experiencing homelessness, who often carry profound and complex trauma histories. TIC shifts the clinical lens from “what is wrong with you?” to “what happened to you?” and emphasizes safety, trust, choice, collaboration, empowerment, and cultural awareness. The chapter compares prominent TIC models, such as those by Harris and Fallot, Hopper et al., and SAMHSA, highlighting common principles while noting the challenge of translating these into clinical practice. Relational psychiatry is presented as central to TIC, with therapeutic relationships acting as key drivers of engagement and recovery. Clinical examples illustrate how staff can operationalize TIC through consistent routines, nondefensive responses, appropriate self-disclosure, and concrete support. The text also addresses the tension between care and coercion, arguing that even involuntary interventions can be trauma-informed if implemented transparently and respectfully. At the organizational level, TIC requires structural changes, training, and reflective practice. Psychologically Informed Environments (PIEs) are introduced as an allied concept that broadens the scope of TIC. The chapter ultimately argues for flexible, compassionate, and relationship-centered approaches that integrate trauma awareness across individual, clinical, and systemic levels of care.