Multiple sclerosis (MS) is the most common disabling condition among young adults, with a myriad of potential effects on neurological function, including sensory and autonomic functions (Kingwell et al. BMC Neurol 13(1):1–13, 2013). MS can also affect sexual function indirectly through other physical disabilities, such as spasticity or bladder dysfunction; as a side effect of medications; and through psychosocial mechanisms, such as the presence of depression (Foley et al. Mult Scler 19(9):1197–203, 2013). A disturbed sexual function can have particularly harmful effects on couple relationships and on the quality of life related to mental health, as is well demonstrated in a large sample of the North American Research Committee on Multiple Sclerosis (NARCOMS) Registry of 6,183 PwMS (Schairer et al. Mult Scler 20(5):610–6, 2014).