While rare, infections of the heart can have severe effects, both during infection and after resolution. These infections are usually caused by an inciting factor, such as bacteria, viruses, or systemic diseases, and are classified based on the area of the heart that is affected: the innermost layer (endocardium), the muscular layer (myocardium), and the outermost layer covering the heart (pericardium). Potential risk factors for these infections include drug use and pre-existing heart conditions. Patients may experience symptoms of fever, chest pain, and chills, and timely blood cultures, and imaging is required to confirm the diagnosis. Treatment strategies vary based on the cause and severity but typically involve medications or surgery. At-risk patients are encouraged to follow preventative strategies, such as vaccination, to reduce their risk of disease and complications.