This chapter focuses on the changes in the last-mile delivery market in terms of its adaptation to ongoing processes and challenges related to both climate policy requirements and growing expectations of authorities and society. The study fits into the broader context of the transformation of the entire transport sector towards achieving climate neutrality. The aim of the study is to identify promising transport and logistics decarbonization tools and assess their importance from the perspective of shaping innovative and zero-emission last-mile delivery strategies. The techniques and research methods used included: content analysis, cause-effect analysis, and applicable quantitative and qualitative analysis methods. These methods were employed to discover and elaborate on the results of the study conducted among representatives of entities carrying out last-mile deliveries. The evaluation of instruments for decarbonizing last-mile deliveries refers to the theory of targeted technological progress in the environmental context. The low-emission transformation of urban transport is one of the priorities of the European Union. The challenges related to last-mile deliveries are causing growing interest in concepts for implementing them in an increasingly sustainable manner. Their implementation is to be supported by actions to reduce the transport intensity of the economy, as well as actions to better organize last-mile logistics.