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Multiple system atrophy (MSA) is a progressive neurodegenerative disorder characterized by a combination of symptoms that affect both the autonomic nervous system (the part of the nervous system that controls involuntary action such as blood pressure or digestion) and movement. Demonstration of nigrostriatal dopaminergic denervation by means of [123I]FP-CIT-SPECT supports the differential diagnosis between to distinguish MSA-c from other causes of cerebellar ataxia. [18F]FDG PET can disclose striatal (mainly putaminal), brainstem, and/or cerebellar hypometabolism, thus differentiating MSA-p and PD when parkinsonism is the main symptom.

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Case 17: Multiple System Atrophy with DAT SPECT and [18F]FDG PET

  • 章节

  • 发表日期：

    2025年

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  • Silvia Morbelli,
  • Dario Arnaldi

摘要

Multiple system atrophy (MSA) is a progressive neurodegenerative disorder characterized by a combination of symptoms that affect both the autonomic nervous system (the part of the nervous system that controls involuntary action such as blood pressure or digestion) and movement. Demonstration of nigrostriatal dopaminergic denervation by means of [123I]FP-CIT-SPECT supports the differential diagnosis between to distinguish MSA-c from other causes of cerebellar ataxia. [18F]FDG PET can disclose striatal (mainly putaminal), brainstem, and/or cerebellar hypometabolism, thus differentiating MSA-p and PD when parkinsonism is the main symptom.