In recent years, the field of disinformation research in the United States has emerged as a prominent area of inquiry across a broad array of social science disciplines, including communication, media studies, political science, psychology, and cybersecurity. This contemporary wave of US disinformation research took shape in response to the global Cambridge Analytica scandal, Russian interference in the 2016 US presidential election, and the election of President Donald Trump. Since then, there has been a considerable number of studies conducted on the content, reception, and production of disinformation. Major findings include the weaponization of disinformation as a tool of societal elites to amass political power, undermine public institutions (particularly relating to public health and democracy), and exacerbate social inequalities. The US has seen significant investment in disinformation research from public and private entities such as the National Science Foundation, John S. and James L. Knight Foundation, and the MacArthur Foundation. The field of disinformation has emerged as a significant topic of study in the US, especially in the wake of the country’s democratic backsliding and the rise of new artificial intelligence technologies that could drastically impact information environments writ large.