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Traumatic brain injury (TBI) remains a significant source of mortality and morbidity throughout the world, in part because of the complex mechanisms. The complexity arises not only from the complicated intracranial biomechanics, but because that mechanical stimulus is only the start of a series of biological responses that unfold over minutes to days after the event. This chapter (co-authors Nevin Varghese and Barclay Morrison) explores the effect on cells of the primary injury that occurs during the mechanical event and the ensuing biological mechanisms of the secondary injury process.

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Cellular Injury Biomechanics of Central Nervous System Trauma

  • 章节

  • 发表日期：

    2025年

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  • Kai-Uwe Schmitt,
  • Duane S. Cronin,
  • Barclay Morrison,
  • Jack P. Callaghan,
  • Markus H. Muser

摘要

Traumatic brain injury (TBI) remains a significant source of mortality and morbidity throughout the world, in part because of the complex mechanisms. The complexity arises not only from the complicated intracranial biomechanics, but because that mechanical stimulus is only the start of a series of biological responses that unfold over minutes to days after the event. This chapter (co-authors Nevin Varghese and Barclay Morrison) explores the effect on cells of the primary injury that occurs during the mechanical event and the ensuing biological mechanisms of the secondary injury process.