This handbook offers a global and interdisciplinary examination of human-animal interactions (HAIs) in the context of climate change and disasters. Drawing from comprehensive literature and policy reviews, case studies, and practitioner insights, the contributors explore HAIs across diverse species, geographies, and disaster types—ranging from wildfires to the COVID-19 global pandemic—emphasizing their impact on resilience, mental health, emergency decision-making, and social cohesion. Key emergent themes include (1) recognizing the social bonds between people and animals, (2) human-centered value assignment of animals and working toward de-anthropocentric frameworks, (3) issues regarding zoonotic disease and public health preparedness, (4) conflicts and geopolitical issues, and (5) emergency management logistics. The volume opens a space beyond human-centric disaster paradigms that considers the role of HAIs in all stages of disaster and emergency management (DEM). Collectively, it advances research, practice, and policy toward inclusive, multispecies resilience and equitable emergency management.