People with (dis)Abilities (PWDs), identified as a vulnerable and marginalized group, are more likely to experience diverse societal challenges (e.g., financial hardships, social isolation and discrimination). COVID-19 not only exacerbated the barriers that existed pre-pandemic but also created new challenges, negatively impacting PWDs’ already weakened health and well-being status. Studies have illustrated that the human-animal bond (HAB) has provided social and health benefits, especially in the context of COVID-19. However, research on the COVID-19-specific experiences of PWDs living with companion animals remains scarce. This comparative case study employed in-depth interviews to investigate the experiences of PWDs with companion animals during the first wave of COVID-19 in two cities: Xi’an, China and Vancouver, Canada, and the completely different public health policies significantly shaped their experiences. Drawing insights from these different experiences and utilizing them to inform PWD-specific support, this study identified three benefits and three challenges. The benefits include (1) physical health, (2) mental health, and (3) individual resilience capacity. Challenges faced by PWDs with companion animals included (1) veterinary care cost and financial burden, (2) accessibility of veterinary care, and (3) concerns about the animals’ well-being. This comparative study highlights the unique needs of PWDs that require individual and community support. Addressing unique demands helps build both individual and community resilience capacity and improves future extreme event preparedness and response.