In the process of checking the fraudulent behavior data of university personnel files by monitoring system, the intelligent monitoring algorithm adopted has certain limitations, which can not cover all abnormal situations, resulting in poor detection effect of the system. Therefore, the intelligent monitoring system of university personnel file fraud data based on wireless network is studied. By initializing the wireless transmission module of the server, read the file information in XML format, and on this basis, define the server data transmission instructions to complete the server design of the intelligent monitoring system. Perfect the connection form of wireless network topology, determine the execution conditions of intelligent monitoring instructions, complete the definition of intelligent monitoring software, and cooperate with the server organization to realize the design of the intelligent monitoring system based on wireless network for college personnel file fraud data. The experimental results show that the application of the above monitoring system can increase the maximum real-time data transmission rate of university personnel file fraud to 9. 5 × 108 bit/ms can effectively guarantee the network host’s ability to accurately monitor information parameters.