In order to improve the real-time control quality level of the linkage numerical control system, the research on the real-time control method of the linkage numerical control system based on human-machine hybrid enhanced intelligence was carried out. First, initialize and configure the linkage CNC system, and set the system to a stable and reliable working state; Secondly, import and analyze processing tasks to avoid processing accidents caused by code errors or parsing problems; On this basis, the real-time control program of the system is designed based on human-machine hybrid to enhance intelligence. The test results show that after the application of the proposed method, the synchronous action load of the system meets the requirements of the interpolation cycle, the response speed is fast, and the machining accuracy is significantly improved.