Patients with mycotic popliteal aneurysm often present with knee pain and fever often without a palpable mass. Untreated popliteal mycotic aneurysms may rupture. Most mycotic popliteal artery aneurysms infected with Staphylococcus epidermidis has an indolent course. The source of infection should be identified and treated immediately. Endovascular repair should be avoided. Complete excision and arterial reconstruction with autologous graft such as greater saphenous vein (GSV) are preferred. Postoperatively, patients should be treated with a minimum of a 6-week course of antibiotics.