Creative industries are becoming an increasingly important driver of economic growth in Russian industrial cities, which calls for a tailored approach to policy development. This study aims to outline a strategy for managing reindustrialization in secondary-tier cities through creative industries, by focusing on the opportunities presented by digital transformation. The authors propose a modular approach to managing creative industries, which allows for differentiated strategies based on three organizational and economic development models: conservation, transformation, and generation. The choice of a model should be based on two key factors: the level of government intervention and the specific characteristics of the creative industries in each city. To maximize the effectiveness of these strategies, it is crucial to adjust them to the unique needs of each creative cluster. It is also proposed to establish an ecosystem of creative industries in Russian second-tier cities on the basis of a digital platform for effective interaction between institutions and organizations providing the process of their management.