Mirador copperCopper-goldGold-silverSilver mineMine is a large-scale open-pit mining operationMining operations located in southern Ecuador, containing 3.2 Mt of copperCopper, 3.4 Moz of goldGold, and 27.1 Moz of silverSilver. After extension, the ore production will increase from the currentCurrent rate of 20 Mt/year to 26.2 Mt/year. Four Ø5 m × 12 m Eriez flotation columnsFlotation column with SlamJet™ Spargers went into production in 2019. The superior cleaner metallurgical performancePerformance of column cells achieved are largely attributed to Eriez SlamJet™, which has a unique geometry for the excellent gas sparging systems and to readily accommodating the use of froth washing systems. This paper presents findings from a study on the effects of various parameters on the full-scale column flotationFlotation performancePerformance. The effects of feed particle size, solids content, froth zone depth, sparger air rate, and wash water rate on the commercial scale column flotationFlotation concentrateConcentrate gradeGrade, enrichment ratio, flotationFlotation yield and recoveryRecovery will be discussed. Under optimized conditions, a concentrateConcentrate of approximately 25% Cu was achieved at over 92% flotationFlotation recoveryRecovery. It was found in the Mirador plant that the combination of fine and ultrafine bubbles produced by specially designed and operated Eriez SlamJet™ Spargers can enhance minus 5 µm ultrafine particles flotationFlotation recoveryRecovery. In this paper, a fundamental study was also performed to improve flotationFlotation selectivity of the minus 5 µm ultrafine particle size fraction.