This chapter explores the multidisciplinary integration of cryoablation in the treatment of bone lesions, emphasizing its practical execution, clinical versatility, and evolving role within modern interventional oncology. Beyond outlining its biological mechanisms, the text provides in-depth guidance on procedural aspects such as anesthesia management, navigation technologies, and safety measures for thermal protection of adjacent structures. Special attention is given to the customization of treatment protocols for a range of bone pathologies—from benign tumors like osteoid osteoma and aneurysmal bone cysts to malignant and metastatic lesions—highlighting the decision-making process between curative and palliative goals. Real-world clinical scenarios, including spine, pelvis, and long bone interventions, are used to illustrate the value of cryoablation in anatomically challenging or surgically inaccessible cases. Adjunctive strategies such as hydrodissection, cementoplasty, and embolization are discussed as essential tools to maximize efficacy and reduce complication rates. Comparative sections examine cryoablation versus other ablative and radiotherapeutic modalities, underscoring the advantages of real-time imaging, patient comfort, and procedural repeatability. Finally, the chapter addresses current limitations and future directions, including immunomodulatory effects and integration with systemic therapies. Overall, this work provides a practical and evidence-based framework for implementing cryoablation in both routine and complex bone tumor management.