This chapter explores the characteristics, clinical applications, and evolving role of radiofrequency ablation (RFA) as a minimally invasive technique for the treatment of bone tumors, with a particular focus on vertebral and extraspinal bone metastases, as well as other applications. RFA operates by delivering controlled thermal energy to targeted lesions, inducing coagulative necrosis and leading to tumor cell destruction. This technique has gained significant traction as an alternative or adjunct to surgery, especially for patients who are not suitable candidates for extensive surgical intervention, require palliative pain relief, or need localized tumor control in anatomically complex regions. A key advantage of modern RFA techniques lies in their integration with advanced imaging modalities such as computed tomography (CT) and fluoroscopy, allowing for precise needle placement and targeted energy delivery while minimizing damage to surrounding healthy tissues. The development of steerable, image-guided ablation devices has further enhanced the efficacy and safety of this approach. Clinical studies have demonstrated that RFA provides significant pain relief, improved functional outcomes, and enhanced quality of life for patients, with relatively low complication rates compared to traditional surgical procedures. Beyond its standalone application, RFA is increasingly being combined with complementary procedures such as cementoplasty and the use of intravertebral fixation devices to enhance structural stability and therapeutic effectiveness, particularly in cases of vertebral involvement. As technology continues to advance, the role of RFA in oncological and palliative care settings is expected to expand, offering patients a less invasive yet highly effective option for managing bone tumors.