With the introduction of lasers into endourological practice, there has been a major paradigm shift in terms of urological interventions. Especially in the last 10 years, Holmium laser enucleation followed by Thulium laser enucleation of the prostate has become increasingly popular in the surgical treatment of lower urinary tract symptoms (LUTS) due to benign prostatic hyperplasia (BPH). With low perioperative complication rates and successful postoperative outcomes, laser enucleation of the prostate (LEP) is now a globally accepted surgical approach for the surgical treatment of LUTS due to BPH. The aim of this chapter is to provide an overview of laser enucleation of the prostate; including operating theatre preparation prior to LEP, different surgical techniques, details of the learning curve, and postoperative complications.