In this paper, I explore the Christian concern that transhumanism is a wrong-headed project because it aims at transforming our God-given human nature in the wrong way. My goal is to show there is no need for a blanket refusal of the transhumanist project. First, I argue that unlike Western Christianity, the teachings of Orthodox Christianity make no ontological commitments to the idea of a God-given fixed human nature. To make my case, I explore the concept of theosis in Eastern Orthodoxy and the concept of matter in the work of Pavel Florensky. The Orthodox concept of theosis presupposes that our human nature is ontologically incomplete. According to Florensky, matter is not reducible to its components and mechanical laws and is always shaped (top-down) by (divine/spiritual/live) form. When combined, these points show there is nothing inherently sinful about human attempts to physically modify/improve. Second, I argue that the demarcation between improvements to our nature that we should pursue and those we should worry about can be found in the Christian imperative to be compassionate with and alleviate the suffering of others. Florensky’s metaphysics of love offers a metaphysical framework for thinking about the ways in which compassion shapes our own nature.