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Yeast Saccharomyces are microscopic fungi consisting of a single spherical cell. They live in a nutritious liquid rich in sugar. Yeast absorbs sugar and releases carbon dioxide. Saccharomyces cerevisiae yeast serves as a classic model for studying radiobiological effects due to its rapid growth, genetic stability, and ease of analysis. Exposure to ionizing radiation, including X-rays, leads to the formation of reactive oxygen species (ROS), which enhance damage to DNA, lipids, and proteins. This phenomenon demonstrates that the radiosensitivity of cells in aerobic conditions is significantly higher than in anaerobic conditions. In this work, the effect of X-ray radiation (50 and 4000 Gy) on the survival of S. cerevisiae yeast in aerobic and anaerobic environments is studied. Additionally, the role of silver nitrate (AgNO₃) at concentrations of 10–2 and 10–3 mol/l as a possible modulator of the radiation response is being studied, which is important for the search for compounds capable of enhancing or reducing radiation exposure.

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Estimation of Radiation Sensitivity of Saccharomyces cerevisiae Yeast Cells Strain T-985 After Exposure to Stress Factor of X-Ray in the Presence and Absence of Silver Cations

  • 会议论文

  • 发表日期：

    2026年

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  • Phyo Myint Oo,
  • V. I. Panfilov,
  • S. V. Kalenov,
  • I. G. Antropova

摘要

Yeast Saccharomyces are microscopic fungi consisting of a single spherical cell. They live in a nutritious liquid rich in sugar. Yeast absorbs sugar and releases carbon dioxide. Saccharomyces cerevisiae yeast serves as a classic model for studying radiobiological effects due to its rapid growth, genetic stability, and ease of analysis. Exposure to ionizing radiation, including X-rays, leads to the formation of reactive oxygen species (ROS), which enhance damage to DNA, lipids, and proteins. This phenomenon demonstrates that the radiosensitivity of cells in aerobic conditions is significantly higher than in anaerobic conditions. In this work, the effect of X-ray radiation (50 and 4000 Gy) on the survival of S. cerevisiae yeast in aerobic and anaerobic environments is studied. Additionally, the role of silver nitrate (AgNO₃) at concentrations of 10–2 and 10–3 mol/l as a possible modulator of the radiation response is being studied, which is important for the search for compounds capable of enhancing or reducing radiation exposure.