Studies on the effectiveness of treatment and utilization of wastewater sludge generated during treatment of municipal, domestic sewage and waterlogged poultry waste. High efficiency of reduction of concentrations of mobile forms of heavy metals (60–99.9%) and pathogenic microorganisms (E. coli, salmonellas) up to (99.9%) by treatment with biopreparation on the basis of lactic acid, proteolytic and cellulosolytic bacteria and sorbent on the basis of sodium humate and dolomite is shown. The method of using wastewater sludge treated by this method in combination with biopreparation and additives of other wastes as fertilizer is proposed. The highest efficiency of growth stimulation of industrial crops (rape) is shown when adding wastewater sludge + biopreparation + (beer production waste—kieselgur) (or sapropel), straw (50–76% in relation to the control).