A significant percentage of patients, according to recent studies, report persistent clinical manifestations of COVID-19 beyond the acute phase. These symptoms extend between four and twelve weeks from the initial clinical presentation. This clinical study details the case of a 50-year-old female patient with a history of hepatitis C who developed COVID-19 and subsequently experienced a series of symptoms indicative of Post-COVID-19 Syndrome (Long COVID). The presented symptoms included fever, general malaise, anorexia, vomiting, diarrhea, sore throat, dry cough, severe headache, mucosal dryness, skin fold, muscle weakness in the lower limbs, conjunctival injection, and sudden visual loss in the left eye. She showed initial improvement and was discharged from the hospital; however, she developed fever, ageusia, dyspnea, positional tachycardia, palpitations, and retrosternal pain. Subsequent examinations revealed pericarditis and subacuteinflammatory demyelinating polyneuropathy, demonstrating the diverse and prolonged clinical course associated with Long COVID. Treatment with colchicine and NSAIDs resulted in clinical improvement, highlighting the challenges in managing and potential therapeutic approaches for patients with persistent COVID-19 symptoms.