Dissection of the head of the pancreas from the portal-mesenteric vein (PMV) during pancreaticoduodenectomy (PD) is a critical step, with a significant risk of iatrogenic injuries, particularly in cases of pancreatic cancer or inflammatory adhesions. These injuries are associated with high morbidity and mortality due to complications like massive bleeding, stenosis, and thrombosis. A safe venous dissection strategy (SVDs) is proposed to mitigate these risks, particularly in situations where the pancreas is adherent to the PMV or in case of large pancreatic masses. The SVDs approach involves two main steps: (Li et al., Asian J Surg 47:63–71, 2024) venous vascular control and (Mandolfino et al., Surg Today 38:1009–1012, 2008) clearance of the superior mesenteric artery (SMA) margin before venous dissection, ensuring safe detachment of the pancreas from the venous axis. Precautionary measures, such as preparing for vascular reconstruction or possible conversion to open surgery, are essential for managing unexpected complications. SVDs should be employed whenever dissection is challenging, aiming to reduce the risk of major bleeding and the need for unplanned vascular resections.