Substance abuse and addiction have long been critical issues in Türkiye, with roots tracing back to the nation’s involvement in the production and export of drugs. While there has been a significant decline in substance abuse-related deaths in recent years, the prevalence of addiction remains a significant concern. This chapter presents evidence of Türkiye’s response to addiction through prevention strategies, legal policies, and rehabilitation efforts. The chapter begins by examining the legal framework surrounding addictive substances and the policies aimed at curbing substance abuse. Key initiatives are highlighted as part of the country’s preventive approach, which includes public awareness campaigns and early intervention efforts. The chapter also delves into the rehabilitation programs designed for individuals suffering from addiction, providing a thorough analysis of Türkiye’s evolving strategy that combines prevention, treatment, and community-based support. The chapter outlines future recommendations for strengthening Türkiye’s fight against substance abuse. These include increased investment in research, improved coordination between governmental and non-governmental organizations, a stronger emphasis on education and community involvement, and enhanced mental health services. By adopting these measures, Türkiye can further enhance its efforts in creating a healthier and more resilient society.