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Exchange between the blood and tissues is the primary function of the microcirculation. The small size and large collective surface area of capillaries facilitate delivery of oxygen, water, and nutrients to the surrounding tissues. However, under inflammatory conditions, the semipermeable barrier of capillaries and postcapillary venules becomes compromised, allowing for excessive leakage of fluids and solutes, which can result in edema. This chapter focuses on the biophysics of fluid and solute exchange across microvascular barriers and the cellular and molecular mechanisms that control microvascular permeability.

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Microcirculatory Exchange Physiology and Molecular Mechanisms Controlling Microvascular Permeability

  • 章节

  • 发表日期：

    2025年

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  • Jerome W. Breslin,
  • Zeinab Y. Motawe,
  • Mengmeng Chang

摘要

Exchange between the blood and tissues is the primary function of the microcirculation. The small size and large collective surface area of capillaries facilitate delivery of oxygen, water, and nutrients to the surrounding tissues. However, under inflammatory conditions, the semipermeable barrier of capillaries and postcapillary venules becomes compromised, allowing for excessive leakage of fluids and solutes, which can result in edema. This chapter focuses on the biophysics of fluid and solute exchange across microvascular barriers and the cellular and molecular mechanisms that control microvascular permeability.