Microfluidic paper-based analytical devices (μPADs) have emerged as transformative tools for food adulteration detection, offering cost-effective, portable, and sustainable solutions. This chapter explores the advancements in μPAD technology, including fabrication methods, sample preparation techniques, and detection strategies. Various fabrication techniques such as photolithography, wax printing, laser cutting, and inkjet printing are discussed, each offering unique precision, resolution, and production efficiency advantages. This chapter emphasizes the importance of sample preparation, highlighting approaches like filtration, solvent extraction, and magnetic separation to improve compatibility with μPAD platforms. Detection strategies ranging from colorimetry to electrochemistry, chemiluminescence, and surface-enhanced Raman spectroscopy (SERS) demonstrate the versatility of μPADs in identifying harmful food contaminants, including pesticides, additives, pathogens, and allergens. Case studies illustrate their applications, such as melamine detection in milk, mercury in fish, and nitrite in meat. Concluding with future perspectives, this chapter underscores the need for enhancing fabrication processes, signal read-out technologies, and field-based applications to facilitate the widespread adoption of μPADs as reliable, accessible tools for ensuring food safety in resource-limited environments.