In this chapter, we review the importance of device-based communications, cross team communications and some methods for team members to collaborate across geographies on a jointly driven project. Obviously, such an endeavor requires a carefully choreographed execution and deployment of the Cloud-based application product. A real-life example of building a Cloud application to migrate medical device data to a public Cloud deployment is presented in this chapter. An introduction to tools such as Github and Jira is given to manage the projects across time zones.