The diagnosis of HCM can be challenging. Echocardiography has become the primary method for the initial evaluation of patients with suspected hypertrophic cardiomyopathy. The integrated utilization of two-dimensional echocardiography, Doppler echocardiography, and stress echocardiography allows for the evaluation of the presence and severity of LV wall thickness, diastolic dysfunction, LVOT obstruction, and mitral regurgitation. Thus, echocardiography offers the clinician a comprehensive imaging modality in those with suspected HCM, as well as those already diagnosed and those undergoing surveillance or therapeutic intervention. In this chapter, we detail the benefits of echocardiography for the diagnosis, monitoring, and management of those with suspected or known HCM.