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Patients with Lynch syndrome have a high risk of colorectal cancer, varying with gender, age, and genotype from 15% to 70% over their lifetime. This compares to a rate of 4.9% for the general population. Patients diagnosed with Lynch syndrome undergo colonic surveillance to protect them against developing cancer. Because of the aggressive tumorigenesis an accurate colonoscopy is essential for this strategy to succeed. This chapter discusses the technique of colonoscopy in high risk patients such as those with Lynch syndrome.

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Lynch syndrome is the “perfect storm” for colorectal carcinogenesis. How do you approach a colonoscopy in patients with a Lynch syndrome genotype? Is it different from your approach in patients who don’t have Lynch syndrome? In what ways?

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  • 发表日期：

    2025年

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  • James M. Church

摘要

Patients with Lynch syndrome have a high risk of colorectal cancer, varying with gender, age, and genotype from 15% to 70% over their lifetime. This compares to a rate of 4.9% for the general population. Patients diagnosed with Lynch syndrome undergo colonic surveillance to protect them against developing cancer. Because of the aggressive tumorigenesis an accurate colonoscopy is essential for this strategy to succeed. This chapter discusses the technique of colonoscopy in high risk patients such as those with Lynch syndrome.