This chapter explores the influence of ambient static pressure on sonochemical processes, with a particular emphasis on the numerical modeling of single-bubble sonochemistry. While experimental observations provide a foundational understanding, the chapter delves into computational findings to offer deeper insights into how static pressure influences cavitation dynamics and chemical activity at the microscopic scale. The discussion begins with an overview of experimental observations to establish context before transitioning to a detailed assessment of numerical simulation results. Computational analyses reveal the complex impact of static pressure, identifying effective optimum points and minimum limits (higher and lower pressures) for sonochemical activity. These findings align with experimental observations, demonstrating that the optimum and limit values vary with frequency, applied acoustic amplitude, and initial cavitation bubble size. A critical analysis of the numerical results is presented to interpret and complement experimental observations, with a focus on single-bubble calculation results.