This chapter is a case study, where the effects of various saturating gases (Air, Ar, O2, He, Xe, or N2) on the production of oxidants (⋅OH, HO2⋅, H2O2, O, and O3), generated by the acoustic cavitation, have been investigated across a range of wave frequencies (200–600 kHz), acoustic intensities (0.7–1.5 W/cm2), and liquid temperatures (15–55 °C). Increased frequency reduces the formation and dissolution of oxidants, with sonochemical activity weakening above ~ 500 kHz. Extending the bubble’s lifetime to a full acoustic cycle increases the dissolution of all oxidants, with the highest dissolution ratio observed at 200–300 kHz. During the collapse phase, the ratio of dissolved oxidants is significantly lower, with a maximum ⋅OH radical dissolution of 1.09% under xenon. Increasing acoustic power from 0.7 W/cm2 to 1.5 W/cm2 enhances the molar formation and dissolution of oxidants across all gases. An optimal acoustic power of 1 W/cm2 maximizes hydroxyl radical production at the end of the collapse phase, yielding 6.44 × 10⁻17 mol for argon and 8.06 × 10⁻17 mol for xenon. An optimal bubble temperature of approximately 5100 K also maximizes ⋅OH radical yield. Among the gases studied, N2 shows the lowest performance, while monoatomic gases exhibit the highest efficiency. Increasing the liquid temperature from 15 to 55 °C boosts the production of all oxidants, regardless of the saturating gas. However, an optimal temperature of approximately 25 °C was found for the dissolution process during the implosion phase, with diminishing improvements in oxidant production at temperatures above 45 °C.