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Non-invasive and, at the same time, efficient techniques for delivering cargo to the interior of eukaryotic cells are the focus of biomedical research. Discoveries in this field could have significant implications for targeted drug delivery. Three nanostructures were considered: carbon nanotubes, graphene planes, and silicon nanospear. In this study, we discuss the relationship between the nanostructure used and its impact on the membrane during the penetration process. All simulations were conducted using a fully atomistic model, at physiological temperature, and in the presence of a water environment. The choice of the least invasive method for nanostructure-assisted drug delivery is crucial for potential applications in medicine. This means that the structure which effectively removes the smallest amount of lipids from the membrane can be considered a potential candidate for drug delivery system. Therefore, the results presented in this work may be helpful in achieving efficient and safe drug delivery using nanomaterials.

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Comparison of the Number of Molecules Extracted from the Phospholipid Bilayer During Its Penetration by Various Nanostructures—MD Study

  • 会议论文

  • 发表日期：

    2026年

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  • Przemyslaw Raczynski,
  • Krzysztof Gorny

摘要

Non-invasive and, at the same time, efficient techniques for delivering cargo to the interior of eukaryotic cells are the focus of biomedical research. Discoveries in this field could have significant implications for targeted drug delivery. Three nanostructures were considered: carbon nanotubes, graphene planes, and silicon nanospear. In this study, we discuss the relationship between the nanostructure used and its impact on the membrane during the penetration process. All simulations were conducted using a fully atomistic model, at physiological temperature, and in the presence of a water environment. The choice of the least invasive method for nanostructure-assisted drug delivery is crucial for potential applications in medicine. This means that the structure which effectively removes the smallest amount of lipids from the membrane can be considered a potential candidate for drug delivery system. Therefore, the results presented in this work may be helpful in achieving efficient and safe drug delivery using nanomaterials.