Buildings have been identified as significant energy users globally. Energy retrofits can significantly reduce building energy consumption. This study presents a method based on assessing performance efficiency, operation efficiency, equipment efficiency and technology efficiency referred to as (POET) framework for holistic identification of energy saving opportunities (ESOs) in a commercial building. This method is applied to a case-study in a commercial building located in South Africa. The paper presents financial, environmental and complexity metrices for evaluating the potential energy saving projects that emanate from the POET framework. All the ESOs promised some reduction in carbon dioxide (CO2) emissions, they also had positive net present value (NPV) values and their payback period (PBP) were a fraction of their useful lives. The ESOs that were identified promise a total monthly energy saving of 163754.22 kWh, which is 85% of the current monthly consumption. The ranking of the ESOs indicated that ESO 1, 2 and 3 could be prioritized immediately with marginal investment to realize 7.4% monthly energy savings, while ESO4, 5, 6 and 7 can be planned for considering the relatively higher complexity and investment requirements.