Recently, designing and evaluating training interventions taking into account Industry 5.0 were suggested, utilizing a specific framework that focuses on job and business modelling. This was the first roadmap for integrating such strategies into companies. However, there are various topics that remain to be reviewed in order for training (or other) interventions to be future-proof, in the sense that they can be agile enough to meet future changes in requirements. Firstly, with the concept of Teaching & Learning Factories lying at the core, the link with other empirical learning techniques needs to be discussed. This is performed through a flexible framework that allows addressing internal needs of companies as well as reproducing organizational aspects in learning ecosystems. This drives the design of a specific interventions’ taxonomy, based on needs. Also, the link to business readiness as well as any respective position (job) requirements, including potential involved industry practices remains to be defined. Furthermore, a taxonomy of industry 5.0 sub-pillars, i.e. related to human centricity, resilience and sustainability, has to be taken into consideration, combined with potential certification levels as well as integrating transformative learning, as applicable. Additionally, an outlook for differentiation between companies and learning ecosystems is given, taking into account an assessment method including a variety of Key Performance Indicators. Finally, extra requirements, such as skills wording and taxonomies, skills dependencies, competencies / capabilities and avoiding pitfalls, such as greenwashing, are discussed.