Interstitial Cystitis/Bladder Pain Syndrome (IC/BPS or “IC”) is a debilitating, chronic pain condition that is highly prevalent in women. The American Urological Association defines IC as an unpleasant sensation, such as pain, pressure, or discomfort, perceived to be related to the bladder, in the absence of infection or other identifiable causes (Clemens, 2022), often paired with urinary frequency and urgency. The pain experienced in IC can be both persistent and accompanied by episodic exacerbations in symptoms (“flares”) that are particularly debilitating. IC interferes with physical, emotional, and social functioning, which can disrupt quality of life and lead to psychological distress. Anxiety, depression, panic attacks, post-traumatic stress disorder, and suicidal ideation are common psychological comorbidities in women with IC. Consistent with AUA recommendations, research highlights the need for biopsychosocial treatment options. A recent randomized controlled trial of a novel cognitive-behavioral intervention for IC (n = 78) found promising effects of cognitive-behavioral self-management on global improvements in physical and psychosocial symptoms (McKernan et al., Pain 165:1748–1760, 2024a). This chapter highlights the treatment protocol using a case example. Considerations for treatment and future research are discussed.