Foreign bodies are responsible for the majority of the granulomatous inflammatory disorders that affect the oral cavity, and numerous foreign materials causing oral lesions have been described in the literature. The clinical manifestation of oral lesions associated with foreign bodies is highly variable and frequently considered nonspecific. For instance, teeth polishing materials may cause a chronically inflamed gingival tissue, while iatrogenically introduced exogenous substances may manifest as painless plaques, swellings, or ulcerations ranging in color from normal to reddish to yellowish aspect, more often affecting the lips, nasolabial fold, and buccal mucosa. The use of cosmetic dermal fillers in the perioral regions has significantly increased in the last years, and a number of granulomatous foreign body reactions associated with these products have also become more common. Microscopically, the inflammatory infiltrate is composed of histiocytes, lymphocytes, and multinucleated giant cells, frequently showing well-formed granulomas. Treatment of granulomatous foreign-body reactions usually comprises the conservative surgical removal of the etiologic substances, which often leads to complete resolution of the signs and symptoms.