Nutraceuticals are extensively explored for management of various types of cancer. They are generally regarded to be neutral and safe and are widely used to promote overall health. Nutraceuticals offer numerous benefits by modifying and maintaining normal body physiological functions. However, the conventional nutraceutical formulations in the market have some major issues that limit their availability in vivo. Majority of the bioactives have limited aqueous solubility leading to poor bioavailability profile. With the advent of nanotechnology some of these limitations have been minimized in the past and investigators have succesfully utilized the benefits of nutraceuticals in vivo for management of cancer. This chapter emphasizes the concerns associated with nutraceuticals and various nanoscale formulation strategies like liposomes, nanoemulsions, nanocrystals, lipid, and polymeric nanoparticles to obtain an insight to how these help in sucessful delivery of bioactives in management of cancer.