Currently, consumers prefer very healthy and nutritious foods in their diet. Fish and fishery products are considered a nutraceutical for providing health benefits to humans. As a result, proteins, peptides, lipids, carbohydrates, pigments, and minerals are explored from marine sources for supply as a nutraceutical or dietary supplement. It has been reported that bioactive peptides from fish protein hydrolysates found to have anticancer, anti-coagulant, anti-diabetic, anti-obesity, hypocholesterolemic effects, antimicrobial, antioxidative, antihypertensive, antithrombotic, and calcium binding activities, etc. Due to nutraceutical effects on human health, marine collagen is also marketed as dietary supplements, capsules, powder drink mixes, syrups, etc. Astaxanthin, from crustaceans, can be used as a dietary supplement with a very potent antioxidant effect on human health. In addition to the consumption of fish, the intake of fish oil-fortified food will meet the daily requirement of omega-3 fatty acids. Chitosan and its oligomer have wider nutraceutical application which includes; wound healing, drug delivery system, hemostatic, lipid absorption reduction, hypocholesterolemic effect, etc. Due to biological activity and non-toxic nature, bioactive from aquatic secondary raw materials can be used for the production of nutraceuticals for human health.