The research on the design of computer information systems based on information technology aims to improve the performance of information recognition, information extraction, and information security operations of computer systems through the utilization of information technology, making the computer technology information system demonstrate high practical application value. Therefore, from the theoretical perspective of information technology, this article provides an overview of the basic content of information technology. Simultaneously, by introducing the key technologies of the computer information system, it provides technical guidance for research. Finally, it elaborates on the specific content of the computer information system design based on information technology. The research results indicate that the research on the design of computer information systems based on information technology can promote the research and development of computer information systems, enhance the security and operational efficiency of computer information systems, and further expand the application scope of computer information systems. This will effectively improve the efficiency of production and management activities in the application fields of computer information systems, as well as increase their economic benefits.