Lifestyle factors have an important influence on the risk of cardiovascular disease and wider non-communicable diseases. The potential for erectile dysfunction (ED) to serve as a sensitive indicator for these conditions highlights how lifestyle risk factors can influence ED risk directly. This chapter explores the link between lifestyle risk factors and the development of ED, highlighting the interrelated nature of these risk factors in pathogenic mechanisms. The potential for lifestyle interventions to modify the risk of ED and to treat this condition is evaluated with respect to published evidence on this topic and the public health implications of such approaches. The potential to modify not only the risk of ED but also the associated conditions for which ED may be a precursor illustrates the importance of effective lifestyle risk factor management in men.