This chapter examines the potential of gamification to promote the skills development of learners with disabilities. Using a desk review approach, this chapter has collected gamification practices that have supported the development of different skills in people with ASD and explored some barriers to effective use in different settings. It also provides some concrete, actionable strategies for educators and administrators to use gamification effectively for inclusion. By providing personalized learning experiences, gamification improves the motivation and social-communicative, motor, and cognitive skills of autistic learners. It also improves academic skills such as vocabulary, pronunciation, and math skills. Challenges such as accessibility of game design, sensory sensitivity, information overload, limited availability of contextualized games, and lack of collaboration to understand the complexity of conditions, learner interests, and game design need to be addressed.