This chapter summarizes some important findings of the Minnesota Longitudinal study carried out by Alan Sroufe, Byron Egeland, Elizabeth Carlson and many other researchers. The study focused on the outcome of children “at psychosocial risk”, i.e. in poverty, with multiple stressors and adverse circumstances. The study highlighted the strong association between a disorganized attachment style during infancy and a number of problematic outcomes, including depression, other emotional problems, suicidality and self-injury. At the same time, it focused on the importance of sensitive caregiving and a more organized strategy to elicit care from adults. The study focuses on the risk and protective factors at different ages of follow up, preschool, school years, adolescence and adulthood. At each stage there are important risk but also opportunities for psychosocial interventions and turning points. Finally, the importance of early identification of children at high risk and the need for early interventions is highlighted.