Companies integrate disruptive technological innovations to strengthen the adaptability of their supply chains in constantly transforming business ecosystems. However, the underlying principles through which these technologies influence supply chain agility remain underexplored. Through a literature review, this article identifies tools of Supply chain 5.0 and factors that drive the adoption of a modern Leagile system. The Fuzzy Hierarchical Analysis Process (FAHP) methodology was applied to select the Supply chain 5.0 criteria with the greatest potential for adaptability, resilience, and productivity, considering the specific characteristics and needs of the sector, and to define the most relevant criteria to ensure a Leagile supply chain. The findings confirm that Cyber Physical System Integration, Multi-scale simulation with digital twins, and hyperpersonalization with Artificial Intelligence are the tools that stand out in this context. Also, variability in the products, Volatile demand and Involvement Supplier the factors that most influence the adoption of the Leagile system. The results provide essential guidelines to facilitate the efficient adoption of Supply chain 5.0 tools, considering the critical factors for Leagile supply chain management.