In this chapter, we will bring the user’s ecosystem to light. Designing within a health ecosystem involves not only consideration for the patient experience, but also situations and environments of use that contribute to a wider set of experiences, interactions, and relationships that, if designed well, can improve outcomes beyond safe and effective use. There are a myriad of touchpoints that make up the ecosystem in which a user will need to navigate in taking their therapy. These touchpoints vary and include their HCP, their pharmacist as well as caregivers. Case studies will be described to provide detail as to how some companies filled knowledge gaps and identified insight to advance therapies.