In today's era of knowledge innovation, STEM workers are the source of motivation for economic progress in many economies, and model-based STEM technical and vocational education is more conducive to establishing students’ entrepreneurial scientific thinking abilities. As a result, this study focuses on 169 students’ assessments and interviews on their entrepreneurial scientific thinking skills following the educational technology experience learning activity. The research results show the following four points: (1) The developed entrepreneurial scientific thinking ability questionnaire has high reliability; (2) This questionnaire is feasible in model-based STEM education; (3) After STEM experiential learning of the entrepreneurial scientific thinking, 47% of students showed high-efficiency entrepreneurial scientific thinking ability; (4) Through thematic interviews, we can better understand the difficulties students face during the experience process, and can use learning experience and interaction to solve technical problems. In the future, STEM learning will enrich the overall ability of entrepreneurial scientific thinking to improve from action, doing and understanding.