The complex of measures for sustainable development of the agro-industrial complex of the Russian Federation in modern crop production is aimed at biologicalisation of technological methods of crop cultivation, which is the key to sustainable development of environmentally safe farming. In the soil and climatic conditions of the South of Russia in the zone of unstable moisture on ordinary chernozem, studies were carried out during 2021–2022. The aim of the research was to determine the possibility of increasing pea productivity with the use of biological preparations. The subject of research were biological preparations: Rizotorfin, Extrasol, Mizorin and Flavobacterin. The plants of Cleopatra variety were the tallest - 70.5 cm, with the highest number of beans - 6.5 pcs/plant. When seeds were treated with rhizotorphin and plants with mizorin, the maximum grain yield of 4.0 t/ha was obtained in cultivation of Cleopatra variety, which is 17.6% more than the control, and is confirmed by the elements of yield structure - the largest number - 28.0 pieces and weight of seeds per plant - 5.7 g. Considering nitrogen removal with grain yield, the greatest effect from the complex application of biopreparations Rhizotorfin and Mizorin was established in the cultivation of Salamanca variety - 12.5%. The maximum profit - 54 907 rub/ha from biopreparations was obtained when seeds of Kleopatra variety were treated with rizotorfin in combination with extrasol, and the level of profitability was 156.5%.