Quantum mechanics is our most successful and versatile account of the basic constituents of matter, of their interaction and of their compounds. We introduce the theory via a sketch of its history and lay out its mathematical structure in some detail. Before this background we address the important and controversial question of how to interpret that structure. We contextualise our own position, which is linked to our account of ontological emergence as detailed in Chap. 2 , and which is mathematically best expressed in the Heisenberg picture of quantum dynamics. Indeterminism and irreversible processes are fundamental for our approach. We discuss the dialectics of the deterministic challenge to our position and argue that indeterminism in the form of quantum randomness has turned from a philosophical riddle to a technological resource. This claim is supported by a discussion of quantum information science, including some of its basic protocols. Towards the end of the chapter we argue that agency and quantum mechanics come as a package deal. For one, quantum mechanics describes the world as offering open possibilities for the future at a fundamental physical level, which is needed for real higher-order organisation, including agency. Of course, this does not in any way show that the actual existence of agents in our world is guaranteed. But it does show that general agency scepticism has no basis in physics. Second, we show that quantum mechanics is best understood as a theory that describes our agential interactions with nature, and not as a theory that represents nature from the point of view of an inert, detached observer.