Lung transplantation has become an increasingly frequent treatment for patients with a variety of end-stage lung diseases. Survival after lung transplantation has improved over time but is still limited as compared to other solid organ transplant recipients. There are a myriad of pulmonary issues that may arise after a lung transplant as well as a large number of non-pulmonary complications frequently related to immunosuppressant effects and/or toxicities. Non-pulmonary complications include but are not limited to renal dysfunction, hematologic abnormalities, gastrointestinal complications, neurologic sequelae, oncologic manifestations, and metabolic derangements. For these reasons, following a lung transplant, recipients require intensive, life-long monitoring for the assessment, evaluation, and management of both allograft and non-allograft, transplant-related complications.