This chapter examines effective and promising city-led urban-violence-prevention and protection practices. It argues that these efforts have the potential to address both structural and acute violence by directing resources toward marginalized places and groups affected by social and economic exclusion, with the aim to mitigate the impact of structural inequalities and historical discrimination. The chapter also highlights how these efforts acknowledge the identities and potential of these marginalized groups as active contributors to solutions. It also discusses how the intentional design and targeting of such policies and programs, guided by an equity-and-justice lens, are evident in the increased incorporation of public health approaches within public policies, with a combination of social interventions and improvements in criminal justice responses, along with enhanced capacities of authorities and communities to prevent violence and improve responses. The integration of a public health approach is particularly crucial for addressing the root causes of various forms of violence, especially identity-based violence, with its systemic and structural drivers. While the chapter acknowledges the challenge of sustaining intervention results, even with a combination of short- and long-term measures, it underscores the ample evidence available from which valuable lessons can be learned.