Humanities and sciences can be viewed as the two domains of human intellectual activities. A dichotomy between them has developed in the last centuries and the gap continues expanding. Several calls have been made to halt and possibly try and reverse the ‘moving apart’ process. This requires the generation of working conceptions of the relationships and synergies between the two domains, together with the awareness of their implementation significance. The present chapter highlights the undesirable impacts of the mutual isolation of the two domains, as they constitute fundamental motivations for efforts aimed at overcoming it. Given the current frequent tendency to somewhat ‘downgrade’ the humanities and ascribe a sort of ‘superior status’ to science and technology, the chapter opts to highlight the undesirable impacts that the impoverishment of humanities-based abilities—such as language mastery and epistemological awareness—brings on science learning, on the very capability to ‘do science’, and on the possibility of safe decisions about the application of new technologies made available by new science discoveries. The discourse is substantiated by a number of concrete examples whose terms are easily evident. It is concluded that building synergies between the two domains is crucial for the future of all human intellectual activities and for development in general.